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Tuberculosis (Edinb). 2011 Mar;91(2):155-72. doi: 10.1016/j.tube.2010.11.009. Epub 2011 Jan 17.

The TB Structural Genomics Consortium: a decade of progress.

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  • 1Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.

Abstract

The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein-protein and protein-ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21247804
[PubMed - indexed for MEDLINE]
PMCID:
PMC3310434
Free PMC Article
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