Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (part I): Structural revision and stereochemical assignment of gephyronic acid

Angew Chem Int Ed Engl. 2011 Jan 24;50(4):938-41. doi: 10.1002/anie.201005530. Epub 2010 Dec 23.

Authors

Lionel Nicolas¹, Timo Anderl, Florenz Sasse, Heinrich Steinmetz, Rolf Jansen, Gerhard Höfle, Sabine Laschat, Richard E Taylor

Affiliation

¹ Department of Chemistry & Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556-5670, USA.

PMID: 21246696
DOI: 10.1002/anie.201005530

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Fatty Acids, Monounsaturated / chemistry
Fatty Acids, Monounsaturated / isolation & purification
Fatty Acids, Monounsaturated / pharmacology
Molecular Structure
Myxococcales / chemistry
Polyketide Synthases / antagonists & inhibitors*
Polyketide Synthases / metabolism
Protein Biosynthesis / drug effects*
Stereoisomerism
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Fatty Acids, Monounsaturated
gephyronic acid
Polyketide Synthases