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Nat Rev Genet. 2011 Feb;12(2):136-49. doi: 10.1038/nrg2904.

Non-coding RNAs as regulators of embryogenesis.

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  • 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA. pauli@fas.harvard.edu


Non-coding RNAs (ncRNAs) are emerging as key regulators of embryogenesis. They control embryonic gene expression by several means, ranging from microRNA-induced degradation of mRNAs to long ncRNA-mediated modification of chromatin. Many aspects of embryogenesis seem to be controlled by ncRNAs, including the maternal-zygotic transition, the maintenance of pluripotency, the patterning of the body axes, the specification and differentiation of cell types and the morphogenesis of organs. Drawing from several animal model systems, we describe two emerging themes for ncRNA function: promoting developmental transitions and maintaining developmental states. These examples also highlight the roles of ncRNAs in ensuring a robust commitment to one of two possible cell fates.

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