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Trends Cardiovasc Med. 1994 Mar-Apr;4(2):77-83. doi: 10.1016/1050-1738(94)90013-2.

Thrombin receptor function and cardiovascular disease.

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  • 1Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0524, USA.


Thrombin, a multifunctional protease generated at sites of vascular injury, is a powerful agonist fora variety of cellular processes important in cardiovascular disease. A recently cloned thrombin receptor has provided a framework for understanding how thrombin, a protease rather than a classic ligand, activates cells. It has also yielded new tools for defining the role of thrombin and its receptor in cellular events. This review discusses a working model for how thrombin activates platelets and other cells, and possible roles for the thrombin receptor in thrombotic, proliferative, and inflammatory processes.

Copyright © 1994. Published by Elsevier Inc.

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