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Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):352-66. doi: 10.1016/j.addr.2011.01.005. Epub 2011 Jan 15.

Skin tissue engineering--in vivo and in vitro applications.

Author information

  • 1Department of Cell and Tissue Engineering, Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, Stuttgart, Germany. katja.schenke-layland@igb.fraunhofer.de

Abstract

Significant progress has been made over the years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as grafts for the replacement of lost skin or for the establishment of human-based in vitro skin models. This review summarizes these advances in in vivo and in vitro applications of tissue-engineered skin. We further highlight novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development and screening.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21241756
[PubMed - indexed for MEDLINE]
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