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Psychopharmacology (Berl). 1990;102(3):414-6.

Fluvoxamine in the treatment of menstrually related mood disorders.

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  • 1Department of General Psychiatry, Psychiatric Hospital Veldwijk, Ermelo, The Netherlands.


Twenty women with premenstrual complaints were treated in a double-blind placebo controlled trial during two consecutive menstrual cycles with fluvoxamine, a selective serotonin uptake blocker. A beneficial effect was found on somatic and affective symptoms in both treatment groups, the effect of fluvoxamine being not different from placebo. The results of this study do not support a role for serotonin in menstrually related affective symptoms.

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