Expression of utrophin at dystrophin-deficient neuromuscular synapses of mdx mice: a study of protected and affected muscles

Anat Rec (Hoboken). 2011 Feb;294(2):283-6. doi: 10.1002/ar.21297. Epub 2010 Dec 2.

Abstract

In mdx mice, intrinsic laryngeal muscles are spared and sternomastoid muscles are affected, showing cycles of muscle regeneration. We observed that utrophin and acetylcholine receptors are fragmented only in affected muscles, providing further evidence that changes in the overall distribution of molecules at dystrophic neuromuscular junctions may be correlated with muscle regeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Dystrophin / deficiency*
  • Laryngeal Muscles / innervation
  • Laryngeal Muscles / metabolism
  • Laryngeal Muscles / pathology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred mdx / metabolism*
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / pathology
  • Muscular Dystrophy, Duchenne / metabolism*
  • Muscular Dystrophy, Duchenne / pathology
  • Neck Muscles / innervation
  • Neck Muscles / metabolism
  • Neck Muscles / pathology
  • Neuromuscular Junction / metabolism*
  • Receptors, Cholinergic / metabolism
  • Regeneration / physiology
  • Synapses / metabolism*
  • Utrophin / metabolism*

Substances

  • Dystrophin
  • Receptors, Cholinergic
  • Utrophin