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Trends Genet. 2011 Mar;27(3):89-97. doi: 10.1016/j.tig.2010.12.001. Epub 2011 Jan 12.

Understanding splicing regulation through RNA splicing maps.

Author information

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK, CB2 0QH.

Abstract

Alternative splicing is a highly regulated process that greatly increases the proteome diversity and plays an important role in cellular differentiation and disease. Interactions between RNA-binding proteins (RBPs) and pre-mRNA are the principle regulator of splicing decisions. Findings from recent genome-wide studies of protein-RNA interactions have been combined with assays of the global effects of RBPs on splicing to create RNA splicing maps. These maps integrate information from all pre-mRNAs regulated by single RBPs to identify the global positioning principles guiding splicing regulation. Recent studies using this approach have identified a set of positional principles that are shared between diverse RBPs. Here, we discuss how insights from RNA splicing maps of different RBPs inform the mechanistic models of splicing regulation.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21232811
[PubMed - indexed for MEDLINE]
PMCID:
PMC3165201
Free PMC Article

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