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    Biomarkers. 2011 Mar;16(2):181-91. Epub 2011 Jan 14.

    Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers.

    Tooker BC, Newman LS, Bowler RP, Karjalainen A, Oksa P, Vainio H, Pukkala E, Brandt-Rauf PW.

    Source

    Division of Allergy and Clinical Immunology, University of Colorado Denver, Aurora, CO 80045, USA. Brian.Tooker@ucdenver.edu

    Abstract

    OBJECTIVES:

    To identify biomarkers for cancer in asbestosis patients.

    METHODS:

    SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer.

    RESULTS:

    Three polypeptide peaks (5707.01, 6598.10, and 20,780.70 Da) could predict the development of cancer with 87% sensitivity and 70% specificity. The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins.

    CONCLUSIONS:

    We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer.

    PMID:
    21231887
    [PubMed - indexed for MEDLINE]

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