J Invest Dermatol. 2011 Feb;131(2):285-7.

The coordinated response of the physical and antimicrobial peptide barriers of the skin.

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Division of Dermatology, Department of Medicine, University of California at San Diego and VA San Diego Health Care System, San Diego, California, USA.

Abstract

Antimicrobial peptides (AMPs) are an essential and multifunctional element for immune defense of the skin during infection and injury. In this issue, Ahrens et al. characterize the response of β-defensins, a class of AMPs, following acute and chronic challenges to the permeability barrier of the skin. Their findings suggest that the antimicrobial and permeability barriers of the skin are closely linked.

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J Invest Dermatol. 2011 Feb;131(2):443-52.

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PMCID:: PMC3121688

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