Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Am Geriatr Soc. 2011 Jan;59(1):101-6. doi: 10.1111/j.1532-5415.2010.03201.x. Epub 2010 Dec 16.

Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study.

Author information

  • 1Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA. ensru001@umn.edu

Abstract

OBJECTIVES:

To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men.

DESIGN:

Prospective cohort study.

SETTING:

Six U.S. community-based centers.

PARTICIPANTS:

One thousand six hundred six men aged 65 and older.

MEASUREMENTS:

25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up.

RESULTS:

After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable.

CONCLUSION:

Lower levels of 25(OH)D (<20.0 ng/mL) in community-dwelling older men were independently associated with greater evidence of frailty at baseline but did not predict greater risk of greater frailty status at 4.6 years.

© 2010, Copyright the Authors. Journal compilation © 2010, The American Geriatrics Society.

PMID:
21226680
[PubMed - indexed for MEDLINE]
PMCID:
PMC3343694
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk