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Pediatr Blood Cancer. 2011 Mar;56(3):488-90. doi: 10.1002/pbc.22827. Epub 2010 Nov 11.

Response of NF1-related plexiform neurofibroma to high-dose carboplatin.

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  • 1Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.


Plexiform neurofibromas (PN) are a hallmark of neurofibromatosis type 1 (NF1). These large nerve tumors can be disfiguring and surgery is the only known standard therapy. Surgical intervention may be suboptimal due to the diffuse nature of PN. Here, we present a case in which we describe the use of high-dose carboplatin to treat the patient's testicular seminoma which resulted in the decrease in size of a PN in a patient with NF1.

Copyright © 2010 Wiley-Liss, Inc.

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