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Mol Cell Biol. 1990 Nov;10(11):6073-8.

Altered transcriptional activity of c-fos promoter plasmids in v-raf-transformed NIH 3T3 cells.

Author information

  • 1Howard Hughes Medical Institute, Department of Biochemistry, New York University Medical Center, New York 10016.

Abstract

In cells transformed by v-raf, an oncogenic counterpart of the serine/threonine kinase Raf-1, regulatory elements of the c-fos promoter were active under conditions of cell growth or stimulation for which they were inactive in untransformed control cells. This suggests that v-raf transforms by deregulating transcription of early response genes.

PMID:
2122238
[PubMed - indexed for MEDLINE]
PMCID:
PMC361409
Free PMC Article
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