Abstract
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection.
MeSH terms
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Drug Resistance, Viral / genetics*
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HIV Infections / virology*
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HIV Integrase / drug effects
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HIV Integrase / genetics*
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HIV Integrase Inhibitors / pharmacology*
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HIV-1 / drug effects
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HIV-1 / enzymology*
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Humans
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Virus Integration / drug effects*
Substances
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HIV Integrase Inhibitors
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HIV Integrase