Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Braz J Infect Dis. 2010 Sep-Oct;14(5):513-8.

Abstract

This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection.

Publication types

  • Review

MeSH terms

  • Drug Resistance, Viral / genetics*
  • HIV Infections / virology*
  • HIV Integrase / drug effects
  • HIV Integrase / genetics*
  • HIV Integrase Inhibitors / pharmacology*
  • HIV-1 / drug effects
  • HIV-1 / enzymology*
  • Humans
  • Virus Integration / drug effects*

Substances

  • HIV Integrase Inhibitors
  • HIV Integrase