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Analyst. 2011 Mar 21;136(6):1103-5. doi: 10.1039/c0an00782j. Epub 2011 Jan 11.

Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN.

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  • 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.

Abstract

Controlled H-aggregation of single Pc-labeled oligonucleotides is utilized as a fluorescence quenching system to discern changes in enzyme activity for the discovery of inhibitors for Long Interspersed Element 1 endonuclease (L1-EN), which is involved in genome instability and implicated in many different diseases.

This journal is © The Royal Society of Chemistry 2011

PMID:
21221467
[PubMed - indexed for MEDLINE]
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