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Antimicrob Agents Chemother. 2011 Apr;55(4):1758-60. doi: 10.1128/AAC.01463-10. Epub 2011 Jan 10.

Decreased susceptibility to ciprofloxacin among Shigella isolates in the United States, 2006 to 2009.

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  • 1Division of Foodborne, Waterborne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. gux8@cdc.gov


We characterized 20 Shigella isolates with decreased susceptibility to fluoroquinolones. Most patients (80%) from whom a travel history was obtained reported travel to South or Southeast Asia. Mutations within the quinolone resistance determining regions of gyrA and parC and plasmid-mediated resistance determinants (qnrB, qnrS, and aac(6')-Ib-cr) were identified. The rise in antimicrobial resistance among Shigella isolates may necessitate the increased use of extended-spectrum cephalosporins or macrolides in some patients.

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