Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Early Hum Dev. 2011 Mar;87(3):183-91. doi: 10.1016/j.earlhumdev.2010.12.002. Epub 2011 Jan 8.

Neurodevelopmental outcome over time of preterm born children ≤750 g at birth.

Author information

  • 1Department of Obstetrics, University Medical Centre, Wilhelmina Children's Hospital, Utrecht, The Netherlands. m.j.claas@umcutrecht.nl

Abstract

BACKGROUND:

Extremely low birth weight (ELBW) infants are at risk of cognitive impairment and follow-up is therefore of major importance. The age at which their neurodevelopmental outcome (NDO) can reliably be predicted differs in the literature.

AIMS:

To describe NDO at 2, 3.5 and 5.5 years in an ELBW cohort. To examine the value of NDO at 2 years corrected age (CA) for prediction of NDO at 3.5 and 5.5 years.

STUDY DESIGN:

A retrospective cross-sectional and longitudinal cohort study.

SUBJECTS:

101 children with a BW≤750 g, born between 1996 and 2005, who survived NICU admission and were included in a follow-up program.

OUTCOME MEASURES:

NDO, measured with different tests for general development and intelligence, depending on age of assessment and classified as normal (Z-score≥-1), mildly delayed (-2≤Z-score<-1) or severely delayed (Z-score<-2).

RESULTS:

At 2, 3.5 and 5.5 years 74.3, 82.2 and 76.2% had a normal NDO. A normal NDO at 2 years CA predicted a normal NDO at 3.5 and 5.5 years in 92% and 84% respectively. Of the children with a mildly or severely delayed NDO at 2 years CA the majority showed an improved NDO at 3.5 (69.2%) and 5.5 years (65.4%) respectively.

CONCLUSIONS:

The majority of the children with a BW≤750 g had a normal NDO at all ages. A normal NDO at 2 years CA is a good predictor for normal outcome at 3.5 and 5.5 years, whereas a delayed NDO at 2 years CA is subject to change with the majority of the children showing a better NDO at 3.5 and 5.5 years.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21220192
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk