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Behav Brain Res. 2011 Jun 1;219(2):358-62. doi: 10.1016/j.bbr.2010.12.033. Epub 2011 Jan 8.

Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice.

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  • 1Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239-3098, USA.


The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.

Copyright © 2011 Elsevier B.V. All rights reserved.

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