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Br J Clin Pharmacol. 2011 Feb;71(2):232-6. doi: 10.1111/j.1365-2125.2010.03824.x.

Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial.

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  • 1University of Paris VII-Denis Diderot, Therapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, Paris, France.



To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.


In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.


The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P=0.94). The day 7-day 1 factor II, R(-) and S(-) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P=0.81, P=0.45, P=0.75, respectively).


Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.

© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.

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