Format

Send to:

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2011 Jan 7;17(1):53-62. doi: 10.3748/wjg.v17.i1.53.

Optical molecular imaging for detection of Barrett's-associated neoplasia.

Author information

  • 1Department of Bioengineering, Rice University, Houston, TX 77005, United States.

Abstract

Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression. This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes. Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption, and autofluorescence imaging that measure changes in endogenous fluorophores. High-resolution imaging approaches include optical coherence tomography, endocytoscopy, confocal microendoscopy, and high-resolution microendoscopy. These technologies, some coupled with an appropriate contrast agent, can measure differences in glandular morphology, nuclear morphology, or vascular alterations associated with neoplasia. Advances in targeted contrast agents are further discussed. Studies that have explored these technologies are highlighted; as are the advantages and limitations of each.

KEYWORDS:

Barrett’s esophagus; Barrett’s metaplasia; Dysplasia; Endoscopy; Esophageal adenocarcinoma; Imaging

PMID:
21218084
[PubMed - indexed for MEDLINE]
PMCID:
PMC3016680
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk