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Indian J Pharm Sci. 2010 Jul;72(4):480-5. doi: 10.4103/0250-474X.73908.

Antiinflammatory, Analgesic and Antipyretic Activities of Mimusops elengi Linn.

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  • 1Department of Pharmacology, KLES's College of Pharmacy, Rajaji Nagar, Bangalore-560 010, India.

Abstract

In the present study, 70% ethanol extract of Mimusops elengi Linn. bark was assessed for antiinflammatory, analgesic and antipyretic activities in animals. The antiinflammatory activity of ethanol extract of Mimusops elengi (200 mg/kg, p.o) was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma models. Analgesic effect was evaluated using acetic acid-induced writhing and Eddy's hot plate models and antipyretic activity was assessed by Brewer's yeast-induced pyrexia in rats. The ethanol extract of Mimusops elengi (200 mg/kg, p.o) significantly inhibited the carrageenan-induced paw oedema at 3rd and 4th h and in cotton pellet model it reduced the transudative weight and little extent of granuloma weight. In analgesic models the ethanol extract of Mimusops elengi decreases the acetic acid-induced writhing and it also reduces the rectal temperature in Brewer's yeast induced pyrexia. However, Mimusops elengi did not increase the latency time in the hot plate test. These results show that ethanol extract of Mimusops elengi has an antiinflammatory, analgesic and antipyretic activity.

KEYWORDS:

Mimusops elengi; analgesic; antiinflammatory; antipyretic; carrageenan

PMID:
21218059
[PubMed]
PMCID:
PMC3013566
Free PMC Article
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