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    Gene. 1990 Sep 14;93(2):277-83.

    Structure and methylation patterns of the gene encoding human carbonic anhydrase I.

    Lowe N, Brady HJ, Barlow JH, Sowden JC, Edwards M, Butterworth PH.

    Source

    Biochemistry Department, University College London, U.K.

    Abstract

    The gene (CAI) encoding human carbonic anhydrase I (CAI) has been isolated and shown to have a total length of 50 kb. Some 36 kb of this consists of a large intron separating the erythroid-specific promoter from the coding region. A small (54 bp) noncoding exon from within this intron is occasionally found in transcripts. Two different polyadenylation sites have been found, the most distal of which is the most commonly used. Methylation levels near the promoter differ widely in cell lines. In CAI-expressing cells, a region of DNA near the promoter is demethylated in a generally highly methylated background. Surprisingly, non-CAI-expressing cell lines show much lower levels of methylation.

    PMID:
    2121614
    [PubMed - indexed for MEDLINE]

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