Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Ethnopharmacol. 2011 Mar 24;134(2):422-8. doi: 10.1016/j.jep.2010.12.045. Epub 2011 Jan 4.

Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients.

Author information

  • 1Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok 65000, Thailand. anjanaf@nu.ac.th

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Bitter melon (Momordica charantia L.) has been widely used as an traditional medicine treatment for diabetic patients in Asia. In vitro and animal studies suggested its hypoglycemic activity, but limited human studies are available to support its use.

AIM OF STUDY:

This study was conducted to assess the efficacy and safety of three doses of bitter melon compared with metformin.

MATERIALS AND METHODS:

This is a 4-week, multicenter, randomized, double-blind, active-control trial. Patients were randomized into 4 groups to receive bitter melon 500 mg/day, 1,000 mg/day, and 2,000 mg/day or metformin 1,000 mg/day. All patients were followed for 4 weeks.

RESULTS:

There was a significant decline in fructosamine at week 4 of the metformin group (-16.8; 95% CI, -31.2, -2.4 μmol/L) and the bitter melon 2,000 mg/day group (-10.2; 95% CI, -19.1, -1.3 μmol/L). Bitter melon 500 and 1,000 mg/day did not significantly decrease fructosamine levels (-3.5; 95% CI -11.7, 4.6 and -10.3; 95% CI -22.7, 2.2 μmol/L, respectively).

CONCLUSIONS:

Bitter melon had a modest hypoglycemic effect and significantly reduced fructosamine levels from baseline among patients with type 2 diabetes who received 2,000 mg/day. However, the hypoglycemic effect of bitter melon was less than metformin 1,000 mg/day.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
21211558
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk