The aim of this study was to evaluate the prevalence of sleep-disordered breathing (SDB) and its relationship with nocturnal denture wear in edentulous subjects. Sixty-two edentulous subjects completed questionnaires to ascertain their risk for SDB; 25 subjects wore dentures during sleep. The prevalence of SDB was 40.3% based on the results of the Berlin Questionnaire. There was no significant difference between high- and low-risk groups with respect to age, Body Mass Index, or denture use, except for a history of self-reported high blood pressure. The prevalence of suspected SDB in edentulous subjects was higher than in the general population.