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Diabetes Res Clin Pract. 2011 Apr;92(1):37-45. doi: 10.1016/j.diabres.2010.12.016. Epub 2011 Jan 3.

Targeting dietary fat or glycemic load in the treatment of obesity and type 2 diabetes: a randomized controlled trial.

Author information

  • 1Department of Psychiatry, University of Pennsylvania School of Medicine, United States. fabricat@mail.med.upenn.edu

Abstract

AIMS:

To compare the effects of lifestyle modification programs that prescribe low-glycemic load (GL) vs. low-fat diets in a randomized trial.

METHODS:

Seventy-nine obese adults with type 2 diabetes received low-fat or low-GL dietary instruction, delivered in 40-week lifestyle modification programs with identical goals for calorie intake and physical activity. Changes in weight, HbA(1c), and other metabolic parameters were compared at weeks 20 and 40.

RESULTS:

Weight loss did not differ between groups at week 20 (low-fat: -5.7±3.7%; low-GL: -6.7±4.4%, p=.26) or week 40 (low-fat: -4.5±7.5%; low-GL: -6.4±8.2%, p=.28). Adjusting for changes in antidiabetic medications, subjects on the low-GL diet had larger reductions in HbA(1c) than those on the low-fat diet at week 20 (low-fat: -0.3±0.6%; low-GL: -0.7±0.6%, p=.01), and week 40 (low-fat: -0.1±1.2%; low-GL: -0.8±1.3%; p=.01). Groups did not differ significantly on any other metabolic outcomes (p≥.06).

CONCLUSIONS:

Results suggest that targeting GL, rather than dietary fat, in a low-calorie diet can significantly enhance the effect of weight loss on HbA(1c) in patients with type 2 diabetes.

Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
21208675
[PubMed - indexed for MEDLINE]
PMCID:
PMC3079199
Free PMC Article
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