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Cell Mol Life Sci. 2011 Jun;68(12):2003-12. doi: 10.1007/s00018-010-0616-z. Epub 2011 Jan 5.

From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase.

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  • 1Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, Mainz, Germany. emkraemer@uni-mainz.de


Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon-glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon-glia interaction mediating myelination.

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