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TRPV Family Ion Channels and Other Molecular Components Required for Hearing and Proprioception in Drosophila .


Kim C.


In: Liedtke WB, Heller S, editors.


TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press; 2007. Chapter 17.
Frontiers in Neuroscience.


In Drosophila, chordotonal sensory organs mediate hearing and proprioception (the body’s awareness of motion and spatial orientation). However, little is known about the mechanisms by which these organs convert mechanical force into the two aforementioned senses. Sensory cilia on the chordotonal neurons are mechanosensitive organelles that carry out mechanical transduction. Recently, various molecular components required for cilia formation and function have been identified. Moreover, two subunits of the Drosophila TRPV (vanilloid receptor–related transient receptor potential) family of ion channels were localized to the sensory cilia of the chordotonal neurons. Current evidence suggests that Drosophila TRPV channels form a mechanotransducer complex that converts mechanical force into a neuronal electrical signal.

Copyright © 2007, Taylor & Francis Group, LLC

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