J Antimicrob Chemother. 1990 Aug;26(2):209-13.

Ceftibuten--in-vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action.

Wise R, Andrews JM, Ashby JP, Thornber D.

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Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.

Abstract

The in-vitro activity of ceftibuten against respiratory pathogenic bacteria was studied and compared with that of other oral beta-lactam agents. Ceftibuten displayed high activity against Haemophilus influenzae and Branhamella catarrhalis. There was reduced activity against Streptococcus pneumoniae (MIC90 16 mg/l). The protein binding of ceftibuten was 77% and the primary target site PBP 3. A high degree of stability to beta-lactamase hydrolysis was observed.

PMID:: 2120175; [PubMed - indexed for MEDLINE]

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