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Cancer Res. 2011 Jan 1;71(1):3-7. doi: 10.1158/0008-5472.CAN-10-2483.

Long intergenic noncoding RNAs: new links in cancer progression.

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  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.

Abstract

The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.

© 2011 AACR.

PMID:
21199792
[PubMed - indexed for MEDLINE]
PMCID:
PMC3057914
Free PMC Article

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