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J Biomed Opt. 2010 Nov-Dec;15(6):060506. doi: 10.1117/1.3523234.

Fiber-optic nonlinear endomicroscopy with focus scanning by using shape memory alloy actuation.

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  • 1Johns Hopkins University, Department of Biomedical Engineering, Baltimore, MD 21205, USA.

Abstract

A miniature fiber optic endomicroscope with built-in dynamic focus scanning capability is developed for the first time for 3-D two-photon fluorescence (TPF) imaging of biological samples. Fast 2-D lateral beam scanning is realized by resonantly vibrating a double-clad fiber cantilever with a tubular piezoactuator. Slow axial scanning is achieved by moving the distal end of the imaging probe with an extremely compact electrically driven shape memory alloy (SMA). The 10-mm-long SMA allows 150-μm contractions with a driving voltage varying only from 50 to 100 mV. The response of the SMA contraction with the applied voltage is nonlinear, but repeatable and can be accurately calibrated. Depth-resolved imaging of acriflavine-stained biological tissues and unstained white paper with the endomicroscope is performed, and the results demonstrate the feasibility of 3-D nonlinear optical imaging with the SMA-based scanning fiber-optic endomicroscope.

PMID:
21198147
[PubMed - indexed for MEDLINE]
PMCID:
PMC3032231
Free PMC Article

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