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Cell Metab. 2011 Jan 5;13(1):11-22. doi: 10.1016/j.cmet.2010.12.008.

NF-κB, inflammation, and metabolic disease.

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  • 1Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21195345
[PubMed - indexed for MEDLINE]
PMCID:
PMC3040418
Free PMC Article
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