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Emerg Infect Dis. 2011 Jan;17(1):107-9. doi: 10.3201/eid1701.091895.

Seasonal influenza A (H1N1) infection in early pregnancy and second trimester fetal demise.

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  • 1University of Michigan Health System, Ann Arbor, Michigan 48901, USA.


A second trimester fetal demise followed influenza-like illness in early pregnancy. Influenza A virus (H1N1) was identified in maternal and fetal tissue, confirming transplacental passage. These findings suggested a causal relationship between early exposure and fetal demise. Management of future influenza outbreaks should include evaluation of products of conception associated with fetal loss.

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