Abstract
Of the 13 strains of Bacillus subtilis tested for the coproduction of the lipopeptide surfactin and the antifungal lipopeptides of the iturin family, only 1 produced both lipopeptides with a high yield. The cultures were made in a synthetic medium. Several L-amino acids and various carbon sources were good substrates for the lipopeptide production. The maximum yield of surfactin was about 110 mg/liter and that of iturin A about 39 mg/liter/absorbance unit for the best strain, B. subtilis S 499.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acids / metabolism
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Anti-Bacterial Agents*
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Antifungal Agents / biosynthesis*
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Antifungal Agents / isolation & purification
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Bacillus subtilis / metabolism*
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / isolation & purification
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Bacterial Proteins / pharmacology
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Carbohydrate Metabolism
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Chromatography, Thin Layer
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Lipopeptides
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Lipoproteins / biosynthesis
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Lipoproteins / isolation & purification
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Lipoproteins / pharmacology
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Molecular Sequence Data
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Peptides*
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Peptides, Cyclic / biosynthesis
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology
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Surface-Active Agents / isolation & purification
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Surface-Active Agents / metabolism*
Substances
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Amino Acids
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Anti-Bacterial Agents
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Antifungal Agents
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Bacterial Proteins
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Lipopeptides
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Lipoproteins
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Peptides
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Peptides, Cyclic
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Surface-Active Agents
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surfactin peptide
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iturin A