Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Epidemiol. 2011 Feb 1;173(3):310-8. doi: 10.1093/aje/kwq400. Epub 2010 Dec 29.

Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1,401 US children.

Author information

  • 1Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale University Schools of Public Health and Medicine, New Haven, Connecticut, USA.

Erratum in

  • Am J Epidemiol. 2011 Apr 1;173(7):846.
  • Am J Epidemiol. 2011 Jun 15;173(12):1475.

Abstract

Many studies have reported that antibiotic use may be associated with increased risk of childhood asthma. Respiratory tract infections in small children may be difficult to distinguish from early symptoms of asthma, and studies may have been confounded by "protopathic" bias, where antibiotics are used to treat early symptoms of asthma. These analyses of a cohort including 1,401 US children assess the association between antibiotic use within the first 6 months of life and asthma and allergy at 6 years of age between 2003 and 2007. Antibiotic exposure was associated with increased risk of asthma (adjusted odds ratio = 1.52, 95% confidence interval (CI): 1.07, 2.16). The odds ratio if asthma was first diagnosed after 3 years of age was 1.66 (95% CI: 0.99, 2.79) and, in children with no history of lower respiratory infection in the first year of life, the odds ratio was 1.66 (95% CI: 1.12, 3.46). The adverse effect of antibiotics was particularly strong in children with no family history of asthma (odds ratio = 1.89, 95% CI: 1.00, 3.58) (P(interaction) = 0.03). The odds ratio for a positive allergy blood or skin test was 1.59 (95% CI: 1.10, 2.28). The results show that early antibiotic use was associated with asthma and allergy at 6 years of age, and that protopathic bias was unlikely to account for the main findings.

Comment in

PMID:
21190986
[PubMed - indexed for MEDLINE]
PMCID:
PMC3105273
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk