Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biophys J. 2011 Jan 5;100(1):80-9. doi: 10.1016/j.bpj.2010.11.002.

Near-critical fluctuations and cytoskeleton-assisted phase separation lead to subdiffusion in cell membranes.

Author information

  • 1Biophysics, BIOTEC, Technische Universität Dresden, Dresden, Germany.

Abstract

We address the relationship between membrane microheterogeneity and anomalous subdiffusion in cell membranes by carrying out Monte Carlo simulations of two-component lipid membranes. We find that near-critical fluctuations in the membrane lead to transient subdiffusion, while membrane-cytoskeleton interaction strongly affects phase separation, enhances subdiffusion, and eventually leads to hop diffusion of lipids. Thus, we present a minimum realistic model for membrane rafts showing the features of both microscopic phase separation and subdiffusion.

Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.

PMID:
21190659
[PubMed - indexed for MEDLINE]
PMCID:
PMC3010007
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk