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Nat Rev Microbiol. 2011 Feb;9(2):109-18. doi: 10.1038/nrmicro2475. Epub 2010 Dec 29.

Genetic control of Candida albicans biofilm development.

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  • 1Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

Abstract

Candida species cause frequent infections owing to their ability to form biofilms - surface-associated microbial communities - primarily on implanted medical devices. Increasingly, mechanistic studies have identified the gene products that participate directly in the development of Candida albicans biofilms, as well as the regulatory circuitry and networks that control their expression and activity. These studies have uncovered new mechanisms and signals that govern C. albicans biofilm development and associated drug resistance, thus providing biological insight and therapeutic foresight.

PMID:
21189476
[PubMed - indexed for MEDLINE]
PMCID:
PMC3891587
Free PMC Article

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