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Dig Dis Sci. 2011 Jun;56(6):1835-47. doi: 10.1007/s10620-010-1505-x. Epub 2010 Dec 28.

Dietary history and physical activity and risk of advanced liver disease in veterans with chronic hepatitis C infection.

Author information

  • 1Section of Health Services Research, Department of Medicine, Baylor College of Medicine, 2450 Holcombe Blvd 01Y, Houston, TX 77021, USA. dwhite1@bcm.edu

Abstract

BACKGROUND:

The role of customary diet and physical activity in development of advanced HCV-related liver disease is not well-established.

METHODS:

We conducted a retrospective association study in 91 male veterans with PCR-confirmed chronic HCV and biopsy-determined hepatic pathology. Respondents completed the Block Food Frequency and the International Physical Activity questionnaires. We conducted three independent assessments based on hepatic pathology: fibrosis (advanced = F3-F4 vs. mild = F1-F2), inflammation (advanced = A2-A3 vs. mild = A1) and steatosis (advanced = S2-S3 vs. mild = S1). Each assessment compared estimated dietary intake and physical activity in veterans with advanced disease to that in analogous veterans with mild disease. Multivariate models adjusted for total calories, age, race/ethnicity, biopsy-to-survey lag-time, BMI, pack-years smoking, and current alcohol use.

RESULTS:

Average veteran age was 52, with 48% African-American. Advanced fibrosis was more prevalent than advanced inflammation or steatosis (52.7% vs. 29.7% vs. 26.4%, respectively). The strongest multivariate association was the suggestive 14-fold significantly decreased advanced fibrosis risk with lowest dietary copper intake (OR = 0.07, 95% CI 0.01-0.60). Other suggestive associations included the 6.5-fold significantly increased advanced inflammation risk with lower vitamin E intake and 6.2-fold significantly increased advanced steatosis risk with lower riboflavin intake. The only physical activity associated with degree of hepatic pathology was a two-fold greater weekly MET-minutes walking in veterans with mild compared to advanced steatosis (P = 0.02).

CONCLUSIONS:

Several dietary factors and walking may be associated with risk of advanced HCV-related liver disease in male veterans. However, given our modest sample size, our findings must be considered as provisional pending verification in larger prospective studies.

PMID:
21188525
[PubMed - indexed for MEDLINE]
PMCID:
PMC3383839
Free PMC Article
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