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    Int J STD AIDS. 2010 Nov;21(11):738-40.

    Virological response with fully active etravirine: pooled results from the DUET-1 and DUET-2 trials.

    Clumeck N, Cahn P, Molina JM, Mills A, Nijs S, Vingerhoets J, Witek J.

    Source

    Division of Infectious Diseases, Saint-Pierre University Hospital, Brussels, Belgium. nathan_clumeck@stpierre-bru.be

    Abstract

    The objective of this subanalysis of the Phase III DUET trials was to examine virological response to an etravirine-containing regimen in patients harbouring virus fully sensitive to etravirine. Full etravirine sensitivity was defined as fold change in 50% effective concentration (FC) ≤3 or weighted genotypic score ≤2. At Week 48 in the etravirine group, 74% of patients with etravirine FC ≤3 and 77% with etravirine genotypic score ≤2 had viral load <50 HIV-1 RNA copies/mL, versus 48% and 46%, respectively, in the placebo group (P < 0.0001). Response rates increased with baseline phenotypic sensitivity score, but were consistently higher with etravirine (56-82%) than placebo (2-72%). Similar observations were made in patients harbouring virus with full etravirine and darunavir sensitivity. Our findings support current recommendations to include three active agents in treatment-experienced patients' regimens.

    PMID:
    21187353
    [PubMed - indexed for MEDLINE]

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