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J Adolesc Health. 2011 Jan;48(1):94-9. doi: 10.1016/j.jadohealth.2010.05.011. Epub 2010 Aug 24.

Transmitted HIV-1 drug resistance among young men of color who have sex with men: a multicenter cohort analysis.

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  • 1Department of Medicine/Division of Infectious Diseases, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599, USA. lisa_hightow@med.unc.edu

Abstract

BACKGROUND:

Given the elevated potential for primary or transmitted drug resistance (TDR) among newly HIV-infected individuals, there is a need for a deeper understanding of the baseline resistance patterns present in young men of color who have sex with men.

METHODS:

Genotypic data were collected for participants aged 13-24 who were enrolled from seven sites. Univariate and bivariate methods were used to describe the prevalence of TDR and characteristics associated with TDR.

RESULTS:

Of the 296 individuals participating in the substudy, 145 (49%) had baseline genotypes. The majority of the individuals were African American (65%) and gay-identified (70%). There was significant variation in genotype availability by site (p < .001). Major surveillance drug resistance mutations were present in 28 subjects (19.3%); the majority were non-nucleoside reverse transcriptase inhibitor mutations (12.4%). Subjects with TDR were less likely to have used alcohol on 1 or more days in the prior 2 weeks. Location was not associated with acquisition of TDR.

CONCLUSIONS:

There was a high rate of TDR in a geographically and racially diverse sample of HIV-infected young men of color who have sex with men. This represents a serious public health concern given the young age of this sample and the potential need for long-term antiretroviral therapy. These findings underscore the critical roles of both early case identification and secondary prevention.

Copyright © 2011 Society for Adolescent Health and Medicine. All rights reserved.

PMID:
21185530
[PubMed - indexed for MEDLINE]
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