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Bioorg Med Chem Lett. 2011 Jan 15;21(2):760-3. doi: 10.1016/j.bmcl.2010.11.108. Epub 2010 Nov 30.

6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.

Author information

  • 1Department of Discovery Chemistry, Ardea Biosciences, Inc., 4939 Directors Place, San Diego, CA 92121, USA.

Abstract

SAR studies on the quinolone carboxylic acid class of HIV-1 integrase inhibitors focused on improving the metabolic stability and led to the discovery of 27 and 38.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
21185178
[PubMed - indexed for MEDLINE]
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