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Eur J Immunol. 2011 Jan;41(1):26-8. doi: 10.1002/eji.201041270. Epub 2010 Dec 9.

γδ T cells develop, respond and survive - with a little help from CD27.

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  • 1Integrated Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA.


Although the TNF receptor family member CD27 has been known for some time, its functional role as a coreceptor on T and B cells remains poorly understood. Recent reports have shown that CD27 and its ligand CD70 play a critical role in the development and function of γδ T cells in mice. In this issue of the European Journal of Immunology, a study now extends these findings to the Vγ9Vδ2(+) subset of human γδ T cells. This subset, whose responses are readily elicited by phosphoantigens, plays an important role in anti-tumor immune responses. This study shows that most Vγ9Vδ2(+) cells express CD27, and signaling via the CD27-CD70 axis is needed for their survival, proliferation and cytokine secretion. Moreover, CD27 functions as a coreceptor, which promotes, in conjunction with TCR-mediated signals, expansion of Th1-biased Vγ9Vδ2(+) cells. This new information underscores the significance of CD27 in γδ T-cell functional differentiation, and is likely to facilitate the development of γδ T-cell-based clinical immunotherapy.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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