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PLoS One. 2010 Dec 16;5(12):e15546. doi: 10.1371/journal.pone.0015546.

MicroRNA-related cofilin abnormality in Alzheimer's disease.

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  • 1Department of Neurology, Weill-Cornell Medical College, New York, New York, United States of America.

Abstract

Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD.

PMID:
21179570
[PubMed - indexed for MEDLINE]
PMCID:
PMC3002958
Free PMC Article

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