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World J Radiol. 2010 Nov 28;2(11):427-33. doi: 10.4329/wjr.v2.i11.427.

Pathophysiology of nephrogenic systemic fibrosis: A review of experimental data.

Author information

  • 1Sameh K Morcos, Department of Diagnostic Imaging, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom.

Abstract

Since the association between nephrogenic systemic fibrosis (NSF) and gadolinium contrast agents (Gd-CAs) was suggested in 2006, several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF. Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells. Low stability agents have also induced NSF-like skin changes in a rat model with normal renal function after multiple repeat administrations. The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.

KEYWORDS:

Experimental models; Gadolinium-based contrast agents; Nephrogenic systemic fibrosis; Pathophysiology

PMID:
21179310
[PubMed]
PMCID:
PMC3006481
Free PMC Article
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