Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
World J Radiol. 2010 Nov 28;2(11):427-33. doi: 10.4329/wjr.v2.i11.427.

Pathophysiology of nephrogenic systemic fibrosis: A review of experimental data.

Author information

  • 1Sameh K Morcos, Department of Diagnostic Imaging, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom.


Since the association between nephrogenic systemic fibrosis (NSF) and gadolinium contrast agents (Gd-CAs) was suggested in 2006, several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF. Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells. Low stability agents have also induced NSF-like skin changes in a rat model with normal renal function after multiple repeat administrations. The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.


Experimental models; Gadolinium-based contrast agents; Nephrogenic systemic fibrosis; Pathophysiology

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk