Crit Rev Oncol Hematol. 2010 Dec 21. [Epub ahead of print]

Nasopharyngeal cancer (NPC) around the Mediterranean area: Standard of care.

Boussen H, Ghorbal L, Naouel L, Bouaouina N, Gritli S, Benna F, Daoud J; on behalf of AROME.

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Department of Medical Oncology, Institut Salah Azaiz, Tunis, Tunisia; Hopital Abderrahman Mami, Ariana, Tunis, Tunisia.

Abstract

Mediterranean area (MA) represents a zone of intermediate incidence (1-5/100,000) for NPC, the highest frequency being observed in North Africa (NA) where it is characterized by a bimodal age repartition due to a first adolescence peak. In MA and NA, NPC remain diagnosed at advanced stages which impact poorly on overall and disease-free survival. It's therapy in MA followed the progresses and standardisation of protocols, based on concomitant chemoradiotherapy (CCRT) alone or preceeded by induction chemotherapy (ICT) in advanced (N2-3, T3-4) stages, while localized cases are managed irradiation alone. NPC overall an disease-free survival improved, due to the use of combined chemo and radiotherapy.

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