Bioessays. 1990 Jun;12(6):259-63.

The synapsins and the regulation of synaptic function.

Bähler M, Benfenati F, Valtorta F, Greengard P.

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Laboratory of Molecular and Cellular Neuroscience, Rockfeller University, New York, NY 10021.

Abstract

Synapsin I and II are a family of synaptic vesicle-associated phosphoproteins involved in the short-term regulation of neurotransmitter release. In this review, we discuss a working model for the molecular mechanisms by which the synapsins act. We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin II.

PMID:: 2117454; [PubMed - indexed for MEDLINE]

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Review Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. [Science. 1989]
Review Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.
Südhof TC, Czernik AJ, Kao HT, Takei K, Johnston PA, Horiuchi A, Kanazir SD, Wagner MA, Perin MS, De Camilli P. Science. 1989 Sep 29; 245(4925):1474-80.
Review Synaptic vesicle phosphoproteins and regulation of synaptic function. [Science. 1993]
Review Synaptic vesicle phosphoproteins and regulation of synaptic function.
Greengard P, Valtorta F, Czernik AJ, Benfenati F. Science. 1993 Feb 5; 259(5096):780-5.
The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1. [J Cell Biol. 1989]
The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1.
Hirokawa N, Sobue K, Kanda K, Harada A, Yorifuji H. J Cell Biol. 1989 Jan; 108(1):111-26.
Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for regulation of neurotransmitter release. [Proc Natl Acad Sci U S A. 1991]
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Benfenati F, Valtorta F, Greengard P. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):575-9.
Review Synapsins as regulators of neurotransmitter release. [Philos Trans R Soc Lond B Biol...]
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Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P. Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28; 354(1381):269-79.

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Cited by 6 PubMed Central articles

Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. [J Biol Chem. 2010]
Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.
Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J, Wang G. J Biol Chem. 2010 Dec 3; 285(49):38630-40. Epub 2010 Oct 4.
Review Neurotransmission and the synaptic vesicle cycle. [Yale J Biol Med. 2002]
Review Neurotransmission and the synaptic vesicle cycle.
Farsad K, De Camilli P. Yale J Biol Med. 2002 Sep-Dec; 75(5-6):261-84.
Src interacts with dynamin and synapsin in neuronal cells. [Proc Natl Acad Sci U S A. 1998]
Src interacts with dynamin and synapsin in neuronal cells.
Foster-Barber A, Bishop JM. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4673-7.

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