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J Org Chem. 2011 Jan 21;76(2):712-5. doi: 10.1021/jo102098y. Epub 2010 Dec 21.

An enyne cycloisomerization approach to the triple reuptake inhibitor GSK1360707F.

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  • 1Chemical Development, GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, North Carolina 27709, United States.


The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial enantioselectivity studies are discussed.

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