Am J Pathol. 1990 Aug;137(2):247-51.

HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. A case report, with analysis of isolated follicular dendritic cells.

Parmentier HK, van Wichen D, Sie-Go DM, Goudsmit J, Borleffs JC, Schuurman HJ.

Source

Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.

Abstract

Follicular dendritic cells (FDC) from axillary lymphoid tissue of a patient with acquired immune deficiency syndrome (AIDS) were analyzed for the presence of gag and env proteins and env mRNA of human immunodeficiency virus type-1 (HIV-1), both in a purified FDC suspension and on frozen sections. Isolated cells with morphologic and immunocytochemical features of FDC expressed HIV-1 core (gag) proteins p15, p17, p24, and envelope (env) protein gp41; in addition HIV-1 env mRNA was detected in some of these cells. This corresponded with intense expression of HIV-1 proteins by FDC in germinal centers in situ, and the presence of HIV-1 mRNA-positive cells in germinal follicles. These findings led us to conclude that FDC are infected and able to produce HIV-1. Such infection may contribute significantly to the destruction of the FDC network during the lymphadenopathy phase after HIV-1 infection.

PMID:: 2117396; [PubMed - indexed for MEDLINE]
PMCID:: PMC1877608

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Expression of RNA and antigens of human immunodeficiency virus type-1 (HIV-1) in lymph nodes from HIV-1 infected individuals. [Am J Pathol. 1988]
Expression of RNA and antigens of human immunodeficiency virus type-1 (HIV-1) in lymph nodes from HIV-1 infected individuals.
Schuurman HJ, Krone WJ, Broekhuizen R, Goudsmit J. Am J Pathol. 1988 Dec; 133(3):516-24.
Cellular composition of germinal centers in lymph nodes after HIV-1 infection: evidence for an inadequate support of germinal center B lymphocytes by follicular dendritic cells. [Clin Immunol Immunopathol. 1992]
Cellular composition of germinal centers in lymph nodes after HIV-1 infection: evidence for an inadequate support of germinal center B lymphocytes by follicular dendritic cells.
Rademakers LH, Schuurman HJ, de Frankrijker JF, Van Ooyen A. Clin Immunol Immunopathol. 1992 Feb; 62(2):148-59.
Monoclonal antibodies to human immunodeficiency virus: their relation to the patterns of lymph node changes in persistent generalized lymphadenopathy and AIDS. [AIDS. 1987]
Monoclonal antibodies to human immunodeficiency virus: their relation to the patterns of lymph node changes in persistent generalized lymphadenopathy and AIDS.
Tenner-Rácz K, Rácz P, Dietrich M, Kern P, Janossy G, Veronese-Dimarzo F, Klatzmann D, Gluckman JC, Popovic M. AIDS. 1987 Jul; 1(2):95-104.
Review Lymphoid changes of the nasopharyngeal and palatine tonsils that are indicative of human immunodeficiency virus infection. A clinicopathologic study of 12 cases. [Am J Surg Pathol. 1996]
Review Lymphoid changes of the nasopharyngeal and palatine tonsils that are indicative of human immunodeficiency virus infection. A clinicopathologic study of 12 cases.
Wenig BM, Thompson LD, Frankel SS, Burke AP, Abbondanzo SL, Sesterhenn I, Heffner DK. Am J Surg Pathol. 1996 May; 20(5):572-87.
Review [Lymphoid tissues and AIDS: role of lymphocytes and follicular dendritic cells (FDC)]. [Verh Dtsch Ges Pathol. 1991]
Review [Lymphoid tissues and AIDS: role of lymphocytes and follicular dendritic cells (FDC)].
Stein H, Spiegel H, Herbst H, Niedobitek G, Foss HD. Verh Dtsch Ges Pathol. 1991; 75:4-19.

See reviews... See all...

Cited by 9 PubMed Central articles

In situ hybridization AT-tailing with catalyzed signal amplification for sensitive and specific in situ detection of human immunodeficiency virus-1 mRNA in formalin-fixed and paraffin-embedded tissues. [Am J Pathol. 2003]
In situ hybridization AT-tailing with catalyzed signal amplification for sensitive and specific in situ detection of human immunodeficiency virus-1 mRNA in formalin-fixed and paraffin-embedded tissues.
Nakajima N, Ionescu P, Sato Y, Hashimoto M, Kuroita T, Takahashi H, Yoshikura H, Sata T. Am J Pathol. 2003 Feb; 162(2):381-9.
Early molecular replication of human immunodeficiency virus type 1 in cultured-blood-derived T helper dendritic cells. [J Clin Invest. 1993]
Early molecular replication of human immunodeficiency virus type 1 in cultured-blood-derived T helper dendritic cells.
Langhoff E, Kalland KH, Haseltine WA. J Clin Invest. 1993 Jun; 91(6):2721-6.
Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution. [Proc Natl Acad Sci U S A. 1993]
Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution.
Embretson J, Zupancic M, Beneke J, Till M, Wolinsky S, Ribas JL, Burke A, Haase AT. Proc Natl Acad Sci U S A. 1993 Jan 1; 90(1):357-61.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

HIV-1 infection and virus production in follicular dendritic cells in lymph node...
HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. A case report, with analysis of isolated follicular dendritic cells.
Am J Pathol. 1990 Aug ;137(2):247-51.

PubMed
Alopecia Areata Associated with Localized Vitiligo.
Alopecia Areata Associated with Localized Vitiligo.
Case Rep Dermatol. 2010 Mar 27;2(1):27-31.

PubMed
Antiphospholipid antibodies and recurrent pregnancy loss: correlation between th...
Antiphospholipid antibodies and recurrent pregnancy loss: correlation between the activated partial thromboplastin time and antibodies against phosphatidylserine and cardiolipin.
Am J Obstet Gynecol. 1990 Aug ;163(2):575-84.

PubMed
A new treatment strategy for acute liver failure.
A new treatment strategy for acute liver failure.
World J Hepatol. 2010 Nov 27 ;2(11):395-400.

PubMed
Non-canonical NF-κB signaling pathway.
Non-canonical NF-κB signaling pathway.
Cell Res. 2011 Jan ;21(1):71-85. Epub 2010 Dec 21 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: