Cell Res. 2011 Jan;21(1):71-85. Epub 2010 Dec 21.

Non-canonical NF-κB signaling pathway.

Source

Department of Immunology, The University of Texas MD Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, Box 902, Houston, TX 77030, USA. ssun@mdanderson.org

Abstract

The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on the inducible processing of p100, a molecule functioning as both the precursor of p52 and a RelB-specific inhibitor. A central signaling component of the non-canonical pathway is NF-κB-inducing kinase (NIK), which integrates signals from a subset of TNF receptor family members and activates a downstream kinase, IκB kinase-α (IKKα), for triggering p100 phosphorylation and processing. A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destruction complex and signal-induced non-canonical NF-κB signaling involves NIK stabilization. Tight control of the fate of NIK is important, since deregulated NIK accumulation is associated with lymphoid malignancies.

PMID:: 21173796; [PubMed - indexed for MEDLINE]
PMCID:: PMC3193406

Free PMC Article

Images from this publication.See all images (3) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. [Sci Signal. 2010]
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G. Sci Signal. 2010 May 25; 3(123):ra41. Epub 2010 May 25.
Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival. [J Biol Chem. 2005]
Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival.
Yang CH, Murti A, Pfeffer LM. J Biol Chem. 2005 Sep 9; 280(36):31530-6. Epub 2005 Jul 11.
Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling. [Sci Signal. 2010]
Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling.
Sun SC. Sci Signal. 2010 May 25; 3(123):pe18. Epub 2010 May 25.
Review Regulation and function of IKK and IKK-related kinases. [Sci STKE. 2006]
Review Regulation and function of IKK and IKK-related kinases.
Häcker H, Karin M. Sci STKE. 2006 Oct 17; 2006(357):re13. Epub 2006 Oct 17.
Review Non-canonical NF-κB signaling activation and regulation: principles and perspectives. [Immunol Rev. 2011]
Review Non-canonical NF-κB signaling activation and regulation: principles and perspectives.
Razani B, Reichardt AD, Cheng G. Immunol Rev. 2011 Nov; 244(1):44-54.

See reviews... See all...

Cited by 7 PubMed Central articles

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway. [Nat Commun. 2012]
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway.
Pone EJ, Zhang J, Mai T, White CA, Li G, Sakakura JK, Patel PJ, Al-Qahtani A, Zan H, Xu Z, et al. Nat Commun. 2012 Apr 3; 3:767. Epub 2012 Apr 3.
NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice. [J Clin Invest. 2011]
NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice.
Murray SE, Polesso F, Rowe AM, Basak S, Koguchi Y, Toren KG, Hoffmann A, Parker DC. J Clin Invest. 2011 Dec; 121(12):4775-86.
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. [PLoS One. 2011]
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.
Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. PLoS One. 2011; 6(8):e23488. Epub 2011 Aug 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Non-canonical NF-κB signaling pathway.
Non-canonical NF-κB signaling pathway.
Cell Res. 2011 Jan ;21(1):71-85. Epub 2010 Dec 21 .

PubMed
Comparing the prevalence of chlamydial infection across populations--what is app...
Comparing the prevalence of chlamydial infection across populations--what is appropriate?
Sex Transm Dis. 2011 Feb ;38(2):79-81.

PubMed
Intraoperative sonography of cervical spinal cord injury: results in 30 patients...
Intraoperative sonography of cervical spinal cord injury: results in 30 patients.
AJR Am J Roentgenol. 1990 Sep ;155(3):603-9.

PubMed
Neoadjuvant and adjuvant strategies in renal cell carcinoma: more questions than...
Neoadjuvant and adjuvant strategies in renal cell carcinoma: more questions than answers.
Anticancer Drugs. 2011 Jan ;22 Suppl 1:S4-8.

PubMed
Osteochondritis dissecans of the knee: value of MR imaging in determining lesion...
Osteochondritis dissecans of the knee: value of MR imaging in determining lesion stability and the presence of articular cartilage defects.
AJR Am J Roentgenol. 1990 Sep ;155(3):549-53.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: