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Pathologica. 2010 Jun;102(3):112-4.

Report of a case of epithelioid hemangioendothelioma of the anterior mediastinum metastatic to pleura.

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  • 1Department of Anatomic Pathology, C Aosta "U. Parini" Hospital, Italy.


We present a case of epithelioid hemangioendothelioma metastatic to pleura, in a 69-year-old woman with chest pain. This distinctive vascular neoplasm can arise in various organs, most commonly in middle-aged women. It is characterized by slow growth, and, microscopically, by epithelioid tumor cells in appearance. Epithelioid hemangioendothelioma should be distinguished mainly from primary or metastatic carcinomas and angiosarcoma. Definitive diagnosis often requires immunohistochemistry. Its clinical course is unpredictable, although survival rates are better than for angiosarcoma.

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