Bull Acad Natl Med. 2010 Mar;194(3):633-45; discussion 645-6.

[Anti-tumoral matrikines: potential interest in oncology].

[Article in French]

Source

Laboratoire de Biochimie et Biologie Moléculaire, CNRS UMR 6237, Université de Reims Champagne-Ardenne, CHU de Reims, 51 rue Cognac Jay - 51095 Reims cedex. fmaquart@chu-reims.fr

Abstract

The word 'matrikine' designates certain peptides derived from partial degradation of extracellular matrix macromolecules and capable of modulating cellular activities. Some matrikines have been shown to inhibit tumor progression and/or neo-angiogenesis, suggesting they may have therapeutic potential. This review examines the main matrikines with anti-tumoral properties, and particularly those originating from basement membrane macromolecules. After a brief description of their discovery and main characteristics, we discuss their mode of production, mechanism of anti-tumor action, and therapeutic potential.

PMID:: 21171255; [PubMed - indexed for MEDLINE]

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